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Homepage > Centers > Catherine E. Costello, Ph.D.
NHLBI Proteomics Administrative and Coordination Center

Boston University Cardiovascular Proteomics Center: Catherine E. Costello, Ph.D.

Catherine E. Costello

Catherine E. Costello, Ph.D.
Professor, Biochemistry, Biophysics and Chemistry at Boston University School of Medicine
Director, Boston University Proteomics Center


The Boston University Cardiovascular Proteomics Center (CPC) is a research institute studying oxidative stress using proteomics technologies. The CPC is investigating post-translational modifications of proteins that are of high importance in the signaling mechanisms altered by oxidative chemical reactions in cardiovascular disease. The CPC is developing and applying new proteomics methodologies and instrumentation for the analysis of known and novel proteins and the qualitative and quantitative determinations of their post-translational modifications.

The Key Investigators

Richard A. Cohen, M.D. Co-PI, Leader for Vascular Biology Project
Wilson S. Colucci, M.D. Co-PI, Leader for Clinical Project
Mark E. McComb, Ph.D. Director, Cardiovascular Proteomics Core Laboratory
Chang-seng Liang, M.D., Ph.D. Director, Cardiomyopathy Program
Lorraine Keane, RN Senior Project Manager
Vasan S. Ramachadran, M.D. Collaborator, BUSM, Framingham Heart Study
Deborah A. Siwik, Ph.D. Laboratory Manager
Christian Schöneich, Ph.D. Chair, Dept. of Pharmaceutical Chemistry, U Kansas

Selected Recent Publications

Vascular aging: Chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Bachschmid MM, Schildknecht S, Matsui R, Zee R, Haeussler D, A Cohen R, Pimental D, Loo BV. Ann Med. 2012 Mar 1. [Epub ahead of print] PMID: 22380696

Oxidation of HRas cysteine thiols by metabolic stress prevents palmitoylation in vivo and contributes to endothelial cell apoptosis. Burgoyne JR, Haeussler DJ, Kumar V, Ji Y, Pimental DR, Zee RS, Costello CE, Lin C, McComb ME, Cohen RA, Bachschmid MM. FASEB J. 2012 Feb;26(2):832-41. Epub 2011 Nov 15. PMID: 22085642 ] PMCID: PMC3290434 [Available on 2013/2/1]

Redox Regulation of SERCA2 Is Required for Vascular Endothelial Growth Factor-Induced Signaling and Endothelial Cell Migration. Evangelista AM, Thompson MD, Weisbrod RM, Pimental DR, Tong X, Bolotina VM, Cohen RA.Antioxid Redox Signal. 2012 May 31. [Epub ahead of print] PMID: 22472004

Cardiovascular Redox and Ox Stress Proteomics. Kumar V, Calamaras TD, Haeussler DJ, Colucci W, Cohen RA, McComb ME, Pimental DR, Bachschmid MM. Antioxid Redox Signal. 2012 May 18. [Epub ahead of print] PMID: 22607061

Differential Characterization and Classification of Tissue Specific Glycosaminoglycans by Tandem Mass Spectrometry and Statistical Methods. Leymarie N, McComb ME, Naimy H, Staples GO, Zaia J. Int J Mass Spectrom. 2012 Feb 15;312:144-154. Epub 2011 Jul 23. PMID: 22523474 [PubMed] PMCID: PMC3329220 [Available on 2013/2/15]

Top-Down Study of β(2)-Microglobulin Deamidation. Li X, Yu X, Costello CE, Lin C, O'Connor PB. Anal Chem. 2012 Jul 17;84(14):6150-7. Epub 2012 Jun 29. PMID: 22746280 [PubMed - in process]

The polyphenols resveratrol and S17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. Qin F, Siwik DA, Luptak I, Hou X, Wang L, Higuchi A, Weisbrod RM, Ouchi N, Tu VH, Calamaras TD, Miller EJ, Verbeuren TJ, Walsh K, Cohen RA, Colucci WS. Circulation. 2012 Apr 10;125(14):1757-64, S1-6. Epub 2012 Mar 2. PMID: 22388319 ] PMCID: PMC3354628 [Available on 2013/4/10]

Autocatalytic Nitration of Prostaglandin Endoperoxide Synthase-2 by Nitrite Inhibits Prostanoid Formation in Rat Alveolar Macrophages. Schildknecht S, Karreman C, Daiber A, Zhao C, Hamacher J, Perlman D, Jung B, van der Loo B, O'Connor P, Leist M, Ullrich V, Bachschmid MM. Antioxid Redox Signal. 2012 Jun 25. [Epub ahead of print] PMID: 22578329

Differentiating N-terminal aspartic and isoaspartic acid residues in peptides. Sargaeva NP, Lin C, O'Connor PB. Anal Chem. 2011 Sep 1;83(17):6675-82. Epub 2011 Aug 1.PMID: 21736361 ] PMCID: PMC3165085 [Available on 2012/9/1]

Dynamics in insulin resistance and plasma levels of adipokines in patients with acute decompensated and chronic stable heart failure. Schulze PC, Biolo A, Gopal D, Shahzad K, Balog J, Fish M, Siwik D, Colucci WS. J Card Fail. 2011 Dec;17(12):1004-11. Epub 2011 Oct 5. PMID: 22123363 ] PMCID: PMC3226951 [Available on 2012/12/1]

High-fat diet increases and the polyphenol, S17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice. Xu S, Jiang B, Hou X, Shi C, Bachschmid MM, Zang M, Verbeuren TJ, Cohen RA. J Cardiovasc Pharmacol. 2011 Sep;58(3):263-71. PMID: 21654327 ] PMCID: PMC3168693 [Available on 2012/9/1]
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