Boston University Cardiovascular Proteomics Center: Catherine E. Costello, Ph.D.
Catherine E. Costello, Ph.D.
Professor, Biochemistry, Biophysics and Chemistry at Boston University School of Medicine
Director, Boston University Proteomics Center
cecmsms@bu.edu
The Boston University Cardiovascular Proteomics Center (CPC) is a research institute studying oxidative stress using proteomics technologies. The CPC is investigating post-translational modifications of proteins that are of high importance in the signaling mechanisms altered by oxidative chemical reactions in cardiovascular disease. The CPC is developing and applying new proteomics methodologies and instrumentation for the analysis of known and novel proteins and the qualitative and quantitative determinations of their post-translational modifications.
The Key Investigators
| Richard A. Cohen, M.D. |
Co-PI, Leader for Vascular Biology Project |
| Wilson S. Colucci, M.D. |
Co-PI, Leader for Clinical Project |
| Mark E. McComb, Ph.D. |
Director, Cardiovascular Proteomics Core Laboratory |
| Chang-seng Liang, M.D., Ph.D. |
Director, Cardiomyopathy Program |
| Lorraine Keane, RN |
Senior Project Manager |
| Vasan S. Ramachadran, M.D. |
Collaborator, BUSM, Framingham Heart Study |
| Deborah A. Siwik, Ph.D. |
Laboratory Manager |
| Christian Schöneich, Ph.D. |
Chair, Dept. of Pharmaceutical Chemistry, U Kansas |
Selected Recent Publications
Peptides Presented by HLA-DR Molecules in Synovia of Patients with Rheumatoid Arthritis or Antibiotic-Refractory Lyme Arthritis. Seward RJ, Drouin EE, Steere AC, Costello CE. Mol Cell Proteomics. 2011 Mar;10 (3):M110.002477, in press.
Redox Regulation of Sirtuin-1 is Mediated by S-Glutathiolation. Zee, R. S.; Yoo, C. B.; Pimentel, D. R.; Perlman, D. H.; Burgoyne, J. R.; Hou, X.; McComb, M. E.; Costello, C. E.; Cohen, R. A.; Bachschmid, M. M. Antioxidants and Redox Signaling. 2010, 13, 1023 - 1032.
Software Tool for Researching Annotations of Proteins: Open-source Protein Annotation Software with Data Visualization. Bhatia VN, Perlman DH, Costello CD, McComb ME. Anal Chem. 2009, 81, 9819-23.
last updated on: May 17, 2012
