Harvard - Broad Proteomics Center: Robert Gerszten, M.D.

Robert Gerszten, M.D.
Director, Translational Research in the Cardiology Division
Director, Harvard – Broad Proteomics Center
Associate Professor of Medicine, Harvard Medical School
Gerszten.Robert@mgh.harvard.edu

Our Center's approach integrates three core components: 1) Proteomic Technology Development led by Dr. Steven Carr (Broad Institute); 2) Molecular Mechanistic and Functional Studies (led by Drs. Anthony Rosenzweig and Robert Gerszten); and 3) Application of Proteomics Approaches to Clinical Questions (led by Drs. Marc Sabatine and Robert Gerszten). The overall goal is to identify new metabolites and proteins that mark disease activity, shed insight into disease progression, and ultimately provide targets for therapeutic intervention.

The Key Investigators

Selected Recent Publications

Integration of proteomic-based tools for improved biomarkers of myocardial injury. Gerszten RE, Carr SA, Sabatine M. Clin Chem. 2010 Feb;56(2):194-201.

Quantification of cardiovascular biomarkers in patient plasma by targeted mass spectrometry and stable isotope dilution. Keshishian H, Addona T, Burgess M, Mani DR, Shi X, Kuhn E, Sabatine MS, Gerszten RE, Carr SA. Mol Cell Proteomics. 2009 Oct;8(10):2339-49.

Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury. Lewis GD, Wei R, Liu E, Yang E, Shi X, Martinovic M, Farrell L, Asnani A, Cyrille M, Ramanathan A, Shaham O, Berriz G, Lowry PA, Palacios IF, Tasan M, Roth FP, Min J, Baumgartner C, Keshishian H, Addona T, Mootha VK, Rosenzweig A, Carr SA, Fifer MA, Sabatine MS, Gerszten RE. J Clin Invest. 2008 Oct;118(10):3503-12

Vascular effects of a low-carbohydrate high-protein diet. Foo SY, Heller ER, Wykrzykowska J, Sullivan CJ, Manning-Tobin JJ, Moore KJ, Gerszten RE, Rosenzweig A. Proc Natl Acad Sci U S A. 2009 Sep 8; 106(36):15418-23.