The Johns Hopkins University Proteomic Innovation Center in Heart Failure

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The mission of the Johns Hopkins Proteomic Innovation Center in Heart Failure is to apply state-of-the-art proteomic methods and develop new approaches and techniques to investigate the biological and clinical aspects of heart failure. Heart failure is a clinical syndrome in which cardiovascular function is insufficient to support the metabolic needs of the body. On a population basis, its burden is substantial and increasing with 5-6 million affected in the United States. Several factors contribute to the etiology and evolution of the clinical presentation including ischemia, hypertension, diabetes and genetic predisposition. Regardless of therapeutic efforts, mortality and morbidity remains high. Many gaps in understanding heart failure remain and it is the goal of this center to identify how heart failure impacts signaling cascades, mitochondrial, contractile, and two new subproteomes (the cell surface and secretory pathway) emphasizing post-translational modifications in order to identify novel ways by which protein modifications either contribute to disease or could be targeted to improve disease outcome.

The central philosophy is that innovative technologies in proteomics are essential to pursue compelling biological and clinical questions.

Links

http://www.hopkinsmedicine.org/proteomics

Publications

https://nhlbi.ctrl.ucla.edu/pages/publications