|last updated on: December 19, 2014||
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Stanford University Proteomics Center: Garry Nolan, Ph.D.
Garry Nolan, Ph.D.
Rachford and Carlota A. Harris Professor, Microbiology and Immunology, Baxter Laboratory for Stem Cell Biology
Director, Proteomics Center at Stanford University
The Stanford NHLBI Proteomics Center brings together an experienced interdisciplinary group of scientists with significant track records in the areas of PAH and autoimmunity, organized around several Cores and five Projects.
Project 1 (led by Drs. Rabinovitch/Nicolls) is investigating the role of viral triggers and inflammatory cells in PAH pathogenesis by using rodent models and patient samples.
Project 2 (led by Dr. Nolan) is developing Phospho-Flow cytometry and mass spectrometry for the isotope-based analysis of signaling pathways at the single-cell level.
Project 3 (led by Dr. Robinson) is characterizing serum autoantibodies and cytokines to define the autoimmune targets associated with disease initiation and progression, with the ultimate goal of developing "clinically actionable" diagnostics for PAH.
Project 4 (led by Dr. Utz) is evaluating the contribution of cytokines, chemokines, growth factors, and signaling pathways to PAH in animals and patients by using the High-throughput Immunophenotyping using Transcription (HIT) and reverse phase lysate microarray proteomics platforms. Project 5 (led by Dr. Kodadek) is developing peptoids as antagonists to perturb cells and as detector molecules to profile lineage-specific cell surface molecules and serum autoantibodies.
The Key Investigators
|Thomas Kodadek, Ph.D.||firstname.lastname@example.org|
|Mark Nicolls, MDemail@example.com|
|Marlene Rabinovitch, M.D.||firstname.lastname@example.org|
|William H. Robinson, M.D., Ph.D.||email@example.com|
|Paul J. Utz, M.D.||firstname.lastname@example.org|
Selected Recent Publications
CytoSPADE: high-performance analysis and visualization of high-dimensional cytometry data. Linderman MD, Bjornson Z, Simonds EF, Qiu P, Bruggner RV, Sheode K, Meng TH, Plevritis SK, Nolan GP. Bioinformatics. 2012 Sep 15;28(18):2400-1. PMID: 22782546 [PubMed - in process]
Multiplexed mass cytometry profiling of cellular states perturbed by small-molecule regulators. Bodenmiller B, Zunder ER, Finck R, Chen TJ, Savig ES, Bruggner RV, Simonds EF, Bendall SC, Sachs K, Krutzik PO, Nolan GP. Nat Biotechnol. 2012 Sep;30(9):858-67. PMID: 22902532 [PubMed - indexed for MEDLINE]
From single cells to deep phenotypes in cancer. Bendall SC, Nolan GP. Nat Biotechnol. 2012 Jul 10;30(7):639-47.
PMID: 22781693 [PubMed - indexed for MEDLINE]
Single-cell mass cytometry adapted to measurements of the cell cycle. Behbehani GK, Bendall SC, Clutter MR, Fantl WJ, Nolan GP. Cytometry A. 2012 Jul;81(7):552-66. PMID: 22693166 [PubMed - indexed for MEDLINE]
Decoupling of tumor-initiating activity from stable immunophenotype in HoxA9-Meis1-driven AML. Gibbs KD Jr, Jager A, Crespo O, Goltsev Y, Trejo A, Richard CE, Nolan GP. Cell Stem Cell. 2012 Feb 3;10(2):210-7. PMID: 22305570 PMCID: PMC3273989 [Available on 2013/2/3]
Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes.Newell EW, Sigal N, Bendall SC, Nolan GP, Davis MM. Immunity. 2012 Jan 27;36(1):142-52. PMID: 22265676
Pathobiology of pulmonary arterial hypertension and right ventricular failure. Voelkel NF, Gomez-Arroyo JG, Abbate A, Bogaard HJ, Nicolls MR. Eur Respir J. 2012 Jun 27. [Epub ahead of print] PMID: 22743666
The intersection of genes and environment: development of pulmonary arterial hypertension in a patient with hereditary hemorrhagic telangiectasia and stimulant exposure. Ayala E, Kudelko KT, Haddad F, Zamanian RT, de Jesus Perez V. Chest. 2012 Jun;141(6):1598-600. PMID: 22670022 [PubMed - in process] PMCID: PMC3367481 [Available on 2013/6/1]
Development and deployment of antigen arrays for investigation of B-cell fine specificity in autoimmune disease. Sokolove J, Lindstrom TM, Robinson WH. Front Biosci (Elite Ed). 2012 Jan 1;4:320-30. PMID: 22201874 PMCID: PMC3404510
Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis. Swanson CD, Akama-Garren EH, Stein EA, Petralia JD, Ruiz PJ, Edalati A, Lindstrom TM, Robinson WH.J Immunol. 2012 Apr 1;188(7):3513-21. Epub 2012 Mar 5. PMID: 22393153 PMCID: PMC3311775 [Available on 2013/4/1]
New tools for classification and monitoring of autoimmune diseases. Maecker HT, Lindstrom TM, Robinson WH, Utz PJ, Hale M, Boyd SD, Shen-Orr SS, Fathman CG. Nat Rev Rheumatol. 2012 May 31;8(6):317-28. doi: 10.1038/nrrheum.2012.66. PMID: 22647780 [PubMed - in process] PMCID: PMC3409841
Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. Sokolove J, Bromberg R, Deane KD, Lahey LJ, Derber LA, Chandra PE, Edison JD, Gilliland WR, Tibshirani RJ, Norris JM, Holers VM, Robinson WH. PLoS One. 2012;7(5):e35296. Epub 2012 May 25. PMID: 22662108 [PubMed - in process] PMCID: PMC3360701
Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies. Liu CL, Tangsombatvisit S, Rosenberg JM, Mandelbaum G, Gillespie EC, Gozani OP, Alizadeh AA, Utz PJ. Arthritis Res Ther. 2012 Feb 2;14(1):R25. PMID: 22300536 [PubMed - in process] PMCID: PMC3392818
|National Heart, Lung, and Blood Institute||National Institutes of Health||Department of Health and Human Services|