|last updated on: April 10, 2014||
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UT Health Science Center at San Antonio Cardiovascular Proteomics Center
Director: Merry L. Lindsey, PhD
The goal of the UTHSCSA Cardiovascular Proteomics Center is to develop novel proteomic technologies to identify predictive markers of adverse remodeling of the left ventricle (LV) following myocardial infarction (MI), focusing on extracellular matrix (ECM) fragment generation as a key initiating event. The three major questions to answer during this contract period are:
- How does ECM proteins differentially produced and proteolytically processed post-MI temporally regulate the remodeling process?
- What are the best standard operating procedures to measure ECM at the proteome level and screen the functional consequence of altered ECM levels post-MI?
- Can ECM proteomics drive the development of better treatment strategies for the post-MI patient?
|National Heart, Lung, and Blood Institute||National Institutes of Health||Department of Health and Human Services|